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Among them, oxidative damage to the autonomic nervous system due to iron accumulation associated with diabetes may be due to changes in the NRF2-GPX4 pathway in ferroptosis (113, 114), the transcription factor that regulates SLC7A11 (51) can effectively prevent oxidative damage in various pathological conditions upon NRF2 activation (115, 116)

Conclusion The potential value of oral L-carnitine in reversing carnitine deficiency and preventing adverse effects due to VPA-induced dysfunction of -oxidation is suggested by several studies and isolated observations